Scientific Publications
Mr Pacifico has been extensively involved in the latest scientific developments in plastic surgery throughout his training period and continues to be at these frontiers. He is passionate about research and his inquisitive mind is forever analysing the challenges he faces as a plastic surgeon, trying to solve the problems encountered.
During Mr Pacifico’s undergraduate medical training he undertook a further year of study to focus on a science degree (a Bachelor in Science (BSc)) in physiology. In this year his research focused on the reactions of blood vessels to variations in temperature, particularly the cold. Blood vessel behaviour and response is fundamental to all areas of plastic surgery. Mr Pacifico was awarded a first class honours degree for the outstanding calibre of his work.
Later during his specialist plastic surgery training Mr Pacifico spent two years researching ways to improve outcomes in melanoma, the most deadly form of skin cancer. To support his research he was awarded a prestigious Royal College of Surgeons Research Fellowship scholarship in 2003. After completion of his work on melanoma, Mr Pacifico was awarded a Doctorate in Medicine (MD) by the University of London.
Mr Pacifico has published extensively in the plastic surgery medical literature, as well as presented at national and international plastic surgery meetings. Below are a list of Mr Pacifico’s scientific publications and presentations.
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Original Articles
- Classification of Breast Implant Malposition.
Aesthet Surg J. 2024 Apr 15:sjae084
- The British Association of Aesthetic Plastic Surgeons (BAAPS) Gluteal Fat Grafting Safety Review and Recommendations.
Aesthet Surg J. 2023 May 15;43(6):675-682
- A Novel Application of the Haemostatic Net in Aesthetic Breast Surgery: A Preliminary Report.
Aesthet Surg J. 2022 Mar 16:sjac058. doi: 10.1093/asj/sjac058. Online ahead of print.PMID: 35294963
- Summary document on safety and recommendations for aesthetic liposuction: Joint British Association of Aesthetic Plastic Surgeons (BAAPS)/British Association of Plastic Reconstructive and Aesthetic Surgeons (BAPRAS) expert liposuction group.
J Plast Reconstr Aesthet Surg. 2022 Mar;75(3):941-947. doi: 10.1016/j.bjps.2021.09.057. Epub 2021 Oct 22.PMID: 34776388
- Safety of Large-Volume Liposuction in Aesthetic Surgery: A Systematic Review and Meta-Analysis.
Aesthet Surg J. 2021 Aug 13;41(9):1040-1053. doi: 10.1093/asj/sjaa338.PMID: 33252626
- Lower Pole Mastopexy-Augmentation: Indications and Applications. Aesthet Surg J. 2020 Feb 6:sjaa039. doi: 10.1093/asj/sjaa039. Online ahead of print.PMID: 32026947
- Reply to: BAPRAS and BAAPS scientific meetings: Are we sticking are noses up at rhinoplasty.
J Plast Reconstr Aesthet Surg. 2019 Feb;72(2):356-362. doi: 10.1016/j.bjps.2018.10.048. Epub 2018 Nov 22.PMID: 30501969
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Columella erosion secondary to nasal prongs in the neonate. Campbell E, Pacifico MD. BMJ Case Rep. 2016 Jun 17;2016
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If a chronic wound does not heal, biopsy it: a clinical lesson on underlying malignancies. Agha RA, Pacifico MD. Cutis. 2016 May;97(5):E12-4
- Re: ‘The rectus sheath and serratus fascia “reverse” fashion flap for the coverage of the lower pole in immediate implant-based breast reconstruction’.Smith OJ, Pacifico M, Ross GL. J Plast Reconstr Aesthet Surg. 2015 Nov;68(11):1626-7.
- Technical refinements of the Wise pattern breast reconstruction.
Odeyinde SO, Pacifico MD. J Plast Reconstr Aesthet Surg. 2014 Aug 15 - Bowel obstruction following DIEP-flap breast reconstruction: an unexpected complication
Mehta S, Blackburn AV, Pacifico MD. J Plast Reconstr Aesthet Surg. 2014 Sep;67(9) - Lateralising paraumbilical medial row perforators: dangers and pitfalls in DIEP FLAP planning: a systematic review of 1116 DIEP flaps.
Kelly JA, Pacifico MD. J Plast Reconstr Aesthet Surg. 2014 Mar;67(3):383-8 - Should we be analysing breast reduction specimens? A systematic analysis of over 1,000 consecutive cases
F Hassan, MD Pacifico. Aesthetic Plast Surg. 2012 Oct;36(5):1105-13 - Exploiting the perforator concept to minimise donor site morbidity in harvesting the radial forearm free flap
MJ Hallam, D Butt, D Coombes, MD Pacifico. Br J Oral Maxillofac Surg. 2012 May 3. - Invited Commentary on: Preliminary report on the use of the SPECTRA implant for the correction of hypoplastic breasts with small-volume asymmetry
MD Pacifico J Plast Reconstr Aesthet Surg. 2012 Mar;65(3):319-20 - Autologous fat grafting to the breast – lessons from stem cell biology
Pearl RA, Leedham SJ, Pacifico MD. J Plast Reconstr Aesthet Surg. 2012 Mar;65(3):283-8 - Refining trunk contouring using the reverse abdominoplasty
MD Pacifico, S Mahendru, RP Teixeira, G Southwick, M Ritz – Aesthet Surg J. 2010 Mar;30(2):225-34 - Correction of senile drooling using the nasolabial sling
MD Pacifico, M Ritz. J Plast Reconstr Aesthet Surg. May 2009 - Fascial Suspension Mastopexy Combined with Augmentation Mammaplasty
M Ritz, S Mahendru, MD Pacifico, O Goldan, RP Teixeira. Aesthetic Plast Surg. 2009 Mar 26 - The Dorsalis Pedis Fascial Flap
M Ritz, N Somia, S Mahendru, MD Pacifico. J Reconstr Microsurg. 2009 Apr 3 - Dynamic Arteries of the Hand
M Ritz, S Mahendru, M Smyth, A Lavoipierre, O Goldan, MD Pacifico. Surg Radiol Anat. 2008 Nov 27 - Incidence of “incidentalomas” in over 100 consecutive CTAs for pre-operative DIEP planning
See MS, Pacifico MD, Harley OJ, Francis I, Smith RW, Jones ME. J Plast Reconstr Aesthet Surg. 2008 Nov 27 - Pre-operative planning for DIEP breast reconstruction: early results in the use of CT-angiography with VoNavix 3D software for perforator navigation
MD Pacifico, M See, N Cavale, J Collyer, M Jones, A Hazari, J Boorman, RW Smith. J Plast Reconstr Aesthet Surg. 2008 Aug 15 - Stratification of patients by melanoma cell adhesion molecule (MCAM) expression on the basis of risk: Implications for Sentinel lymph node biopsy
RA Pearl, MD Pacifico, FD Daley, PR Barber, B Vojnovic, F Buffa, PI Richman, G Wilson, R Grover. J Plast Reconstr Aesthet Surg. 2008; 61(3): 265-271 - The government two-week rule and its impact on melanoma prognosis: an evidence-based study
MD Pacifico, R Pearl, R Grover. Ann R Coll Surg Engl. 2007; 89(6):609-15 - The Differential Fascial Glide: a technical refinement in abdominoplasty
P Mallucci, MD Pacifico, N Waterhouse, W Sabbagh. J Plast Reconstr Aesthet Surg. 2007; 60: 929-933 - Ki-67 Expression in Melanoma. A Potential Method of Risk Assessment for the Patient with a Positive Sentinel Node
RA Pearl, MD Pacifico, PI Richman, DJ Stott, GD Wilson, AO Grobbelaar. J Exp Clin Cancer Res. 2007; 26(1): 109-115 - The tuberous breast revisited
MD Pacifico, NV Kang. J Plast Reconstr Aesthet Surg. 2007;60(5):455-64 - The Use of a Cocktail of Single Chain Fv Antibody Fragments to Improve the In Vitro and In Vivo Targeting of Melanoma
MD Pacifico, R Pearl, J Kupsch. J Exp Clin Cancer Res, 2006 25(1):45-54 - CD44v3 levels in primary cutaneous melanoma are predictive of prognosis: assessment by the use of tissue microarray
MD Pacifico, R Grover, P Richman, F Daley, F Buffa, GD Wilson. Int J Cancer. 2006 Mar;118(6):1460-4 - Nm23 as a prognostic marker in primary cutaneous melanoma: evaluation using tissue microarray in a patient group with long-term follow-up
MD Pacifico, R Grover, P Richman, F Daley, F Buffa, GD Wilson. Melanoma Res. 2005 Oct;15(5):435-40 - Identification of P-cadherin in primary melanoma using a tissue microarrayer: prognostic implications in a patient cohort with long-term follow-up
MD Pacifico, R Grover, P Richman, F Daley, F Buffa, GD Wilson. Ann Plast Surg. 2005 Sep;55(3):316-320 - Development of a tissue array for primary melanoma with long-term follow-up: discovering MCAM as an important prognostic marker
MD Pacifico, R Grover, P Richman, F Daley, F Buffa, GD Wilson. Plast Reconstr Surg. 2005 Feb;115(2):367-75 - Validation of tissue microarray for immunohistochemical profiling of melanoma
MD Pacifico, R Grover, P Richman, F Daley, GD Wilson. Melanoma Res. 2004 Feb;14(1):39-42 - Use of an early-detection strategy to improve disease control in melanoma patients
MD Pacifico, R Grover, R Sanders. Br J Plast Surg 2004 Feb; 57 (2): 105-111 - Effect of imidazole on the solubility of his-tagged antibody fragments
S Hamilton, J Odili, M Pacifico, GD Wilson, J-M Kupsch. Hybridoma and Hybridomics. 2003 Dec; 22 (6): 347-55 - Use of oncogene expression as an independent prognostic marker for primary melanoma
R Grover, MD Pacifico, GD Wilson, R Sanders. Annals Plast. Surg. 2003 Feb; 50 (2): 183-187 - Long-term results of distal pancreatectomy for chronic pancreatitis
RR Hutchins, RS Hart, M Pacifico, RCN Williamson. Ann Surg 2002 Nov; 236 (5): 612-8
- Classification of Breast Implant Malposition.
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Short Reports & Correspondence
- Reply to: Mortality Rate in Breast Implant Surgery: Is an Additional Procedure Worthwhile to Mitigate BIA-ALCL Risk?
Aesthetic Plast Surg. 2023 Jun;47(3):927-929
- Commentary on: Polydioxanone Monofilament Mesh: A Safety Net for Complex Breast Implant Revision Surgery.
Aesthet Surg J. 2023 Feb 21;43(3):NP167-NP169
- Commentary on: The Use of DCE-MRI to Evaluate the Blood Supply to the Nipple-Areola Complex: A Study in 245 Asian Women.
Aesthet Surg J. 2021 May 18;41(6):NP355-NP356
- A solution to the high-riding nipple-areola complex
BA Frenkiel, MD Pacifico, G Southwick. Accepted for publication by Aesthetic Plastic Surgery - Suturing of fragile skin
MD Pacifico, RP Teixeira, M Ritz. J Plast Reconstr Aesthet Surg. 2009 Apr 24 - The elliptical punch biopsy: a simple technique
BA Frenkiel, MD Pacifico, M Ritz. J Plast Reconstr Aesthet Surg. 2009 Feb 18 - Keloids: when excision is the better part of valour
D Marsh, MD Pacifico, D Gault. Plast Reconstr Surg. 2008 Apr;121(4):214e-5e - Treatment of severe recalcitrant pyoderma gangrenosum with anti-TNF-α drug – Etanercept
FJ Rogge, MD Pacifico, N Kang. J Plast Reconstr Aesthet Surg. 2008;61(4):431-3 - Further reporting of tibial stress fractures complicating free fibula grafts
MD Pacifico, Floyd D, Wood SH. J Plast Reconstr Aesthet Surg. 2008;61(3):346 - Earlobe perforation after prolonged use of a topical corticosteroid
F Rogge, MD Pacifico, AO Grobbelaar. J Plast Reconstr Aesthet Surg. 2007;60(1):100-1 - Massive haemorrhage following punch-biopsy of a longstanding ulcer
B Rudge, N Jallali, MD Pacifico, NV Kang. J Plast Reconstr Aesthet Surg. 2007;60(9):1078-9 - Compartment Syndrome as a result of intramuscular anabolic steroid injection
M Akhavani, MD Pacifico, NV Kang. Injury Extra 2006 37:407-8 - Mustard burns to the index finger
B Rudge, MD Pacifico, N Jallali, AO Grobbelaar. BMJ “Minerva” section. 2005 3rd Dec 331:1348 - Tibial stress fracture as a complication of free-fibula vascularised graft for mandibular reconstruction
MD Pacifico, Floyd D, Wood SH. Br J Plas Surg. 2003 Nov; 56 (8): 832-834 - Demonstrating in the light of MRCS
M Pacifico. Surgery 1999 May; 17: 5
- Reply to: Mortality Rate in Breast Implant Surgery: Is an Additional Procedure Worthwhile to Mitigate BIA-ALCL Risk?
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National & International Scientific Presentations
- Aesthetic breast contouring using autologous fat: a note of caution.
RA Pearl, S Leedham, MD Pacifico
Presented at the British Association of Aesthetic Plastic Surgeons Annual Meeting, Royal College of Physicians, September 2011 - Autologous fat grafting to the breast – lessons from stem cell biology.
MD Pacifico, RA Pearl, S Leedham
Presented at the British Association of Plastic, Reconstructive and Aesthetic Surgeons Annual Meeting, Royal College of Surgeons of England, December 2011 - Where is Breast Reconstruction Headed in the UK? Urgent Rethink for the Future of our Specialty
MD Pacifico, E Sassoon, ME Jones, C Nduka, RW Smith. Winter BAPRAS scientific meeting, 2-4 December 2009, Royal College of Surgeons, London, UK - Concepts in surgery on the tuberous breast.
A Greensmith, MD Pacifico, NV Kang. 8th Advanced Plastic Surgery Workshop, 2nd- 6th February 2009, Melbourne, Australia - Our early experience with the Quill SRS.
MD Pacifico, S Mahendru, G Southwick, M Ritz. The Australian Society of Plastic Surgeons biannual meeting, 2nd-5th October 2008, Broadbeach, Gold Coast, Australia - DIEP perforator mapping using VoNavix 3-D software – the future of flap planning?
M See, MD Pacifico, N Cavale, J Collyer, M Jones, A Hazari, J Boorman, RW Smith. The British Association of Plastic, Reconstructive & Aesthetic Surgeons Summer meeting, 9th-11th July 2008, Liverpool, UK - Pre-operative planning for DIEP breast reconstruction: early results in the use of CT-angiography with VoNavix 3D software for perforator navigation.
M See, MD Pacifico, N Cavale, J Collyer, M Jones, A Hazari, J Boorman, RW Smith. International symposium on plastic surgery, 25th-28th June 2008, Bologna, Italy - Stratification of risk in Melanoma Patients in the basis of MCAM Expression: Implications for Sentinel Node Biopsy.
RA Pearl, MD Pacifico, FM Daley, F Buffa, P Barber, B Vojnovic, PI Richman and R Grover, British Association of Plastic Surgeons Winter Meeting, 30th November, 1-2 December 2005. The Royal College of Surgeons, London - A novel pathophysiological classification of the tuberous breast: justification and surgical application.MD Pacifico, NV Kang. The British Association of Aesthetic Plastic Surgeons 2005, The Royal College of Physicians, London
- The role of P-cadherin expression in melanoma progression and its relevance to patient outcome.
RA Pearl, MD Pacifico, FM Daley, F Buffa, PI Richman, R Grover. The 9th European Conference of Scientists and Plastic Surgeons, Leuven, Belgium, 16th – 17th September 2005 - Identification of MCAM as a prognostic marker in melanoma by tissue array.
MD Pacifico, R Grover, P Richman, F Daley, F Buffa, J Kupsch, R Sanders, GD Wilson. The 7th European Conference of Scientists and Plastic Surgeons, Geneva, Switzerland. 19th -20th September 2003 - Melanoma targeting with a cocktail of single chain Fvs to distinct determinants on human melanoma.
MD Pacifico, NV Kang, J Odili, J-M Kupsch, R Sanders. The 15th European Immunology Conference, Rhodes, Greece. 9th – 13th June 2003 - Use of a cocktail of single chain Fvs to target distinct determinants on human melanoma.
MD Pacifico, NV Kang, J Odili, J-M Kupsch, R Sanders. The 3rd Research Meeting on Melanoma, Milan, Italy. 26th -28th May 2003 - An early detection strategy to improve the survival of melanoma patients.
MD Pacifico, R Grover, R Sanders. The 3rd Research Meeting on Melanoma, Milan. 26th -28th May 2003 - Improving survival in melanoma: long-term evaluation of an early detection clinic reviewing 4399 patients.
MD Pacifico, R Grover, R Sanders. Winter BAPS 2002. The Royal College of Surgeons of England, November 2002 - Improving the survival in melanoma with an early detection clinic.
M Pacifico, R Grover, R Sanders. The 6th European Conference of Scientists and Plastic Surgeons. Vienna, 27th – 28th September 2002 - Long-term results of distal pancreatectomy for chronic pancreatitis.
R Hutchins, RS Hart, M Pacifico, RCN Williamson. The Association of Surgeons of Great Britain & Ireland meeting, Birmingham, 2001
- Aesthetic breast contouring using autologous fat: a note of caution.
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Book Chapters
- Cell Adhesion Molecule Expression in Melanoma Progression – The Staging System of the Future? MD Pacifico, RA Pearl, G Wilson. Chapter in “Progress in Skin Cancer Research”, part of the “Horizons in Cancer Research” series; Nova Science Publishers, Inc. 2007 (VL Heinz Editor); pp.105-124
- Hypospadias Correction: 1 or 2 stages? NV Kang, MD Pacifico. Chapter in “Evidence for Plastic Surgery”, TFM Publishing Ltd. 2007 (Chris Stone Editor); pp.159-169
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Published Abstracts
- The role of P-cadherin expression in melanoma progression and its relevance to patient outcome. RA Pearl, MD Pacifico, FM Daley, F Buffa, PI Richman, R Grover. J Plast Reconstr Aesthet Surg. 2006 Sep; 59 (9): S2-S3
- Identification of MCAM as a prognostic marker in melanoma by tissue array.
MD Pacifico, R Grover, P Richman, F Daley, F Buffa, J Kupsch, R Sanders, GD Wilson. The European Journal of Plastic Surgery 2005 - Use of a cocktail of single chain Fvs to target distinct determinants on human melanoma.
MD Pacifico, NV Kang, J Odili, J-M Kupsch, R Sanders. Melanoma Research 2004 - An early detection strategy to improve the survival of melanoma patients.
MD Pacifico, R Grover, R Sanders. Melanoma Research. 14(2):S29-S29, April 2004 - Melanoma targeting with a cocktail of single chain Fvs to distinct determinants on human melanoma.
MD Pacifico, NV Kang, J Odili, J-M Kupsch, R Sanders. Immunology Letters 2003 June; 87 (1-3): 207 - Improving the survival in melanoma with an early detection clinic.
MD Pacifico, R Grover, R Sanders. Accepted for publication in the European Journal of Plastic Surgery - Long-term results of distal pancreatectomy for chronic pancreatitis.
RR Hutchins, RS Hart, M Pacifico, RCN Williamson. British Journal of Surgery (88), suppl.1. 2001, p58
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My experience at Purity Bridge was flawless; from consultation, to surgery and then the aftercare I received... I felt so well looked after by Mr Pacifico and his clinical team – such lovely warm, caring and knowledgeable nursing team… My results have exceeded my expectations – book a consultation with Mr Pacifico if you are considering surgery.
– RealSelf Patient Review
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From the first time I met Marc I knew he was the right surgeon for me. He put me at ease, answered all of my questions and was realistic in terms of results… I cannot recommend Marc enough to anyone considering surgery. The results of the breast augmentation and mastopexy are better than I could have imagined and I am so glad that I chose Purity Bridge for my journey.
– H. Trustpilot Review
Tuberous Breasts Treated with Lift and Fat Grafting
… Although medically they are not tuberous breasts, I was later told they do have a tubular shape which has made me insecure since puberty… Mr Pacifico’s attentiveness, expertise and qualifications made him an obvious choice. He is extremely talented and knowledgable… this surgery was 100% the right decision.
– RealSelf Patient Review